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Converting Target Discovery and Validation into Drug Discovery and Drug Development – Especially for Childhood Cancers
Dr. Donald Durden 

A renowned physician-scientist, Donald Durden, M.D., PhD., is Vice Chair for Research at UC San Diego’s Department of Pediatrics and Associate Director for Pediatric Oncology at the UC San Diego Moores Cancer Center. Durden’s most recent accomplishment is the development and initiation of a clinical trial of the first small molecule inhibitor of PI-3 kinase to enter human clinical trials in cancer.

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About the Lab 

About the Durden Lab

The main focus of the Durden laboratory is analyzing mouse models for pediatric cancer in order to better understand signaling pathways that contribute to cancer cell growth. As a result, Durden et al hope to identify the most powerful drug targets for pediatric disease intervention.

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News and Updates 

Cancer Metastasis Regulators found to work with Cellular Network

A new study published in April, 2014 in the journal PLoS One by researchers in the Department of Pediatrics and UCSD School of Medicine has identified a new group of proteins within the macrophage which regulate cancer metastasis suggesting a new avenue for potential treatment of metastatic disease.